Hematological Profiling and Biochemical Parameters Analysis in Female Breast Cancer

Abstract

Breast cancer is the most common cancer affecting women worldwide. It occurs when abnormal cells in the breast grow uncontrollably and form a tumor. Thirty-two serum specimens were taken from women and were divided into two groups: 15 samples from women with breast cancer and 17 from healthy women as a control group in Al-Amal Hospital for Oncology and Alnahreen center/Baghdad City, from the period March 2024 to December 2025. The results revealed that the breast cancer cases had a mean level of Hb of (12.73±0.18) compared to the healthy women (12.84±0.16) with no important variations, P=0.64. In addition, the mean levels of WBC count were (6905.26±448.33) compared to the controls (6881.76±412.34), P=0.96, and the PTL was (302.26±16.97) in comparison to the healthy females (298.23±19.03), P=0.87. Furthermore, the mean range of CRP in women with breast cancer was (2.07±0.32) compared to the control patients (1.03±0.16), with significant differences, P=0.006. While the mean range of CA15.3 was (60.45±23.50) compared to the healthy control (9.20±0.82), with an important difference, P=0.02. Moreover, the level of DHEA was elevated in breast cancer cases (278.68±33.40) in comparison to the control females, P ≤ 0.01. On the other hand, the range of CYP450 was (270.77±30.57) compared to the controls (52.84±13.35) with a highly significant differences P≤ 0.01.